Asymmetric Electrospun Nanofiber Composed Of Polycaprolactone, Chitosan, and Curcumin To Promote Chronic Wound Healing

Chronic wounds are a growing medical issue around the world, with 2.4 - 4.5 million people afflicted in United States alone. The condition currently makes up 2-3% of healthcare costs for developed countries, and this number is expected to increase as chronic wound-causing problems, like diabetes, grow prevalence. Due lack effective wound dressings, face higher risk bacterial infection express high morbidity mortality rates. Many current dressings homogeneous fail account complexities different layers skin. Alternatively, asymmetric electrospun nanofibers have bilayer design that corresponds skin’s dermis epidermis. We intend demonstrate an nanofiber composed polycaprolactone (PCL), chitosan (CS), curcumin (Cur) can be utilized dressing. These three biodegradable biocompatible components were applied mimic protective epidermis porous dermis. Upon electrospinning our running it through scanning electron microscope, we found hydrophobic PCL layer had low porosity (52.16%) thin (281.82 nm), while hydrophilic PCL/CS/Cur (61.18%) thick (425.54 nm). Our was also more at resisting permeation than nanofiber. results highlight superiority membranes suggest further experimentation, establish viable